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The publications contained in this archive section are provided for historical purposes only. The views expressed in the publications are those of their respective authors and do not reflect the views of NOXXON. NOXXON disavows any obligation to update or correct the information contained in these publications.

Monzel C, Becker AS, Saffrich R, Wuchter P, Eckstein V, Ho AD, Tanaka M.
Dynamic cellular phynotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents.
Sci Rep. 2018, 8(1), 1841.
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Weisberg EL, Sattler M, Azab AK, Eulberg D, Kruschinski A, Manley PW, Stone R, Griffin JD.
Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition.
Oncotarget. 2017, 8(66), 109973-84.
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Ludwig H, Weisel K, Petrucci MT, Leleu X, Cafro AM, Garderet L, Leitgeb C, Foa R, Greil R, Yakoub-Agha I, Zboralski D, Vauléon S, Dümmler T, Beyer D, Kruschinski A, Riecke K, Baumann M, Engelhardt M.
Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib – dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study.
Leukemia. 2017, 31, 997-1000.
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Deng L, Stafford JH, Liu SC, Chernikova SB, Merchant M, Recht L, Martin Brown J.
SDF-1 Blockade Enhances Anti-VEGF Therapy of Glioblastoma and Can Be Monitored by MRI.
Neoplasia. 2017, 19(1), 1-7.
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Zboralski D, Hoehlig K, Eulberg D, Froemming A, Vater A.
Increasing tumor-infiltrating T cells through inhibition of CXCL12 with NOX-A12 synergizes with PD-1 blockade.
Cancer Immunol Res. 2017.
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Waldschmidt JM, Simon A, Wider D, Müller SJ, Follo M, Ihorst G, Decker S, Lorenz J, Chatterjee M, Azab AK, Duyster J, Wäsch R, Engelhardt M.
CXCL12 and CXCR7 are relevant targets to reverse cell adhesion-mediated drug resistance in multiple myeloma.
Br J Haematol. 2017, 179(1), 36.
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Boels MGS, Koudijs A, Avramut MC, Sol WMPJ, Wang G, van Oeveren-Rietdijk AM, van Zonneveld AJ, de Boer HC, van der Vlag J, van Kooten C, Eulberg D, van den Berg BM, IJpelaar DHT, Rabelink TJ.
Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.
Am J Pathol. 2017.
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Devarapu SK, Kumar Vr S, Rupanagudi KV, Kulkarni OP, Eulberg D, Klussmann S, Anders HJ.
Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis.
Clin Immunol. 2016.
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Menne J, Eulberg D, Beyer D, Baumann M, Saudek F, Valkusz Z, Więcek A, Haller H.
C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria.
Nephrol Dial Transplant. 2016.
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Hoehlig K, Klussmann S.
Spiegelbildliche Nukleinsäuren als pharmakologische Wirkstoffe.
Chemie in unserer Zeit 2015, 49(6), 422-5.
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Hoehlig K, Klussmann S.
Molekulare Schere.

Chemie in unserer Zeit
2015, 49(6), 421.
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Kalnins A, Thomas MN, Andrassy M, Müller S, Wagner A, Pratschke S, Rentsch M, Klussmann S, Kauke T, Angele MK, Bazhin AV, Fischereder M, Werner J, Guba M, Andrassy J.
Spiegelmer Inhibition of MCP-1/CCR2 - Potential as an Adjunct Immunosuppressive Therapy in Transplantation.
Scand J Immunol. 2015, 82(2), 102.
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Brockmann C, Brockmann T, Dege S, Busch C, Kociok N, Vater A, Klussmann S, Strauß O, Joussen AM.
Intravitreal inhibition of complement C5a reduces choroidal neovascularization in mice.
Graefes Arch Clin Exp Ophthalmol. 2015.
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Oberthür D, Achenbach J, Gabdulkhakov A, Buchner K, Maasch C, Falke S, Rehders D, Klussmann S, Betzel C.
Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.
Nature Commun. 2015, 6, 6923.
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Yatime L, Maasch C, Hoehlig K, Klussmann S, Andersen GR, Vater A.
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nature Commun. 2015, 6, 6481.
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Mavroidis M, Davos CH, Psarras S, Varela A, C Athanasiadis N, Katsimpoulas M, Kostavasili I, Maasch C, Vater A, van Tintelen JP, Capetanaki Y.
Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy.
Basic Res Cardiol. 2015, 110(3), 485.
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Haller H, Menne J, Baumann M, Eulberg D.
CCL2 Inhibition with Emapticap Pegol (NOX-E36) in Type 2 Diabetic Patients with Albuminuria.

ISN World Congress of Nephrology
2015, Cape Town

Benedetti E, Duchemin N, Bethge L, Vonhoff S, Klussmann S, Vasseur JJ, Cossy J, Smietana M, Arseniyadis S.
DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis.
Chem. Comm. 2015, 51(28), 6076-9.
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Hoehlig K, Bethge L, Klussmann S.
Stereospecificity of Oligonucleotide Interactions Revisited: No Evidence for Heterochiral Hybridization and Ribozyme/DNAzyme Activity.
PLoS One. 2015, 10(2), e0115328.
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Hoehlig K, Johnson KW, Pryazhnikov E, Maasch C, Clemens-Smith A, Purschke W, Vauléon S, Buchner K, Jarosch F, Khiroug L, Vater A, Klussmann S.
A Novel CGRP-neutralizing Spiegelmer Attenuates Neurogenic Plasma Protein Extravasation.
Br.J.Pharmacol. 2015.
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Vater A, Klussmann S.
Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer therapeutics.
Drug Discovery Today. 2015, 20(1), 147-155.
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