Usage of Cookies
We use cookies to better understand your use of this website. This enables us to improve your future experience on our website. Detailed information about our use of cookies can be found in our privacy policy. If you continue to use this website we will assume that you agree with the usage of cookies. You can prevent cookies from being installed or delete them from your computer. How this works, is explained in our privacy policy. Imprint

NOX-E36 (emapticap pegol) binds and neutralizes the human chemokine CCL2, also referred to as MCP-1 (C-C Chemokine Ligand 2 / Monocyte Chemoattractant Protein 1 and the related chemokines CCL8, CCL11 and CCL13). MCP-1/CCL2 is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in a variety of inflammatory diseases and are implicated in cancer spread and immune privilege of tumors.

NOX-E36 was originally developed in diabetic nephropathy where it completed a Phase 2a exploratory study which included 76 patients with Type 2 diabetes and proteinuria on top of standard of care.

Recent clinical studie available at

  • NOX-E36 in Patients With Type 2 Diabetes Mellitus and Albuminuria
    (ref: NCT01547897)
    Status: completed

Recent NOX-E36 press releases

NOX-E36 press release archive

NOX-E36 publication archive